IMR Press / FBS / Volume 10 / Issue 2 / DOI: 10.2741/S514

Frontiers in Bioscience-Scholar (FBS) is published by IMR Press from Volume 13 Issue 1 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.


Neuroprotective role of Asiatic acid in aluminium chloride induced rat model of Alzheimer’s disease

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1 Department of Biochemistry and Biotechnology, Annamalai University, Annamalainagar, Tamil Nadu 608002, India
2 Department of Food Science and Nutrition, CAMS, Sultan Qaboos University, Muscat, Oman
3 Ageing and Dementia Research Group, Sultan Qaboos University, Muscat, Oman
4 Food and Brain Research Foundation, Chennai, Tamil Nadu 600094, India
5 Neuroinflammation group, Faculty of Medicine and Health Sciences, Macquarie University, NSW, Australia

*Author to whom correspondence should be addressed.

Front. Biosci. (Schol Ed) 2018, 10(2), 262–275;
Published: 1 January 2018

Alzheimer’s disease (AD) is the most common form of dementia, characterized by memory loss, cognitive impairment and personality disorders accompanied by diffuse structural abnormalities in the brain of elderly people. The current investigation explored the neuroprotective potential of asiatic acid (AA), a natural triterpene of Centella asiatica on aluminium chloride (AlCl3) induced rat model of AD. Oral administration of AlCl3 (100 mg/kg b.w.) for 42 days significantly elevated the levels of Al, activity of acetyl cholinesterase and expressions of amyloid precursor protein, amyloid beta1–42, beta and gamma secretases, glial fibrillary acidic protein, ionized calcium binding adaptor molecule 1, interleukins -1β, 6, 4, 2, tumor necrosis factor alpha, inducible nitric oxide synthase, nuclear factor- k beta and cyclooxygenase-2 in the hippocampus and cortex compared to the control group. Our observations suggested that AA treatment mitigated AlCl3 induced AD associated pathologies, which might be due to its multiple pharmacological actions. Further studies are necessary in order to explore the link between AlCl3-mediated oxidative stress and associated apoptosis to establish its neuroprotective role in AD.

Alzheimer’s disease
Asiatic Acid
Memory Deficits
Amyloid Pathology
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