IMR Press / FBS / Volume 10 / Issue 1 / DOI: 10.2741/S503

Frontiers in Bioscience-Scholar (FBS) is published by IMR Press from Volume 13 Issue 1 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.


Multifactorial role of long non-coding RNAs (LncRNAs) in hematopoiesis

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1 Cell and molecular biology lab, department of zoology, university of the Punjab, lahore, Pakistan
2 Centre for Applied Molecular Biology, university of the Punjab, lahore, Pakistan

*Author to whom correspondence should be addressed.

Front. Biosci. (Schol Ed) 2018, 10(1), 119–126;
Published: 1 January 2018

Human genome project unveiled that only 1.5.-2.0.% of the genome is protein coding. ENCODE and related studies showed that most part of the genome transcribed into RNAs, and most of them do not code for a functional proteins, hence the name non-coding RNAs (ncRNAs). ncRNAs are small ncRNAs (less than 200 nucleotides) and long ncRNAs (longer than 200 nucleotides up to 10 kb). They act as a direct link between highly ordered chromosome structures, gene expression and serve as a bridge between genome and chromatin modification complexes as guides, scaffolds, and decoys. Highly regulated hematopoietic differentiation is required for formation of all types of blood cells. Among a variety of lncRNAs only few hematopoitic lncRNAs have been studied extensivelyand most of them are not functionally characterized. The role of these lncRNAs remains partially undetermined but their involvement in the regulation of various genes and protein synthesis has been proved even in hematopoiesis. So, the present review is a mere effort to highlight the role of lncRNAs involved in the development and regulation of hematopoiesis.

Blood cells
Gene expression
Long non-coding RNAs
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