IMR Press / FBS / Volume 10 / Issue 1 / DOI: 10.2741/S502

Frontiers in Bioscience-Scholar (FBS) is published by IMR Press from Volume 13 Issue 1 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Review

Molecular evolution of hemagglutinin gene of Influenza A virus

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1 School of Biotechnology, Adamas University, Barasat, Kolkata 700126, WB, India
2 Centre for Interdisciplinary Research and Education, Jodhpur Park, Kolkata 700068, WB, India

*Author to whom correspondence should be addressed.

Front. Biosci. (Schol Ed) 2018, 10(1), 101–118; https://doi.org/10.2741/S502
Published: 1 January 2018
Abstract

In the history of human civilization, influenza is the second most catastrophic killer disease for mankind with plague ranking first in the medieval times. The 1918-1919 ‘Spanish flu’ killed 20-50 million people worldwide. According to a report from WHO, there have been four pandemics, several epidemics and recurrent seasonal outbreaks of influenza in different parts of the world. The virus is a potential bioterrorism threat with biological ‘Chernobyl-like disaster’ that occurred in Soviet Russia in 1977. Here, the author reviews the biology of the surface exposed hemagglutinin of the influenza virus, a gene under constant positive selection pressure to evade host immunity and vaccination. Global, local and seasonal outbreaks of influenza lead to a significant number of deaths both in humans and poultry birds.

Keywords
Hemagglutinin
Influenza A virus
Pandemic
Evolution
Epidemic
Review
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