IMR Press / FBS / Volume 1 / Issue 1 / DOI: 10.2741/S5

Frontiers in Bioscience-Scholar (FBS) is published by IMR Press from Volume 13 Issue 1 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Imaging reactive oxygen species dynamics in living cells and tissues
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1 Department of Primary Care Medicine, College of Medicine, National Taiwan University, 1 Section 1 Jen-Ai Road, Taipei, Taiwan
2 Department of Internal Medicine, College of Medicine, National Taiwan University, 1 Section 1 Jen-Ai Road, Taipei, Taiwan
3 Graduate Institute of Biomedical Engineering, College of Medicine, National Taiwan University, 1 Section 1 Jen-Ai Road, Taipei, Taiwan

*Author to whom correspondence should be addressed.

Academic Editor: Jaw-Wen Chen

Front. Biosci. (Schol Ed) 2009, 1(1), 39–44; https://doi.org/10.2741/S5
Published: 1 June 2009
Abstract

Reactive oxygen species (ROS) can mediate cellular signal transduction, destroy hazardous foreign pathogens, regulate transcriptional activities and therefore are essential in normal cellular physiology. On the other hand, inadequate control of ROS production can induce peroxidation of essential biomolecules and result in cellular dysfunction. In the worst condition even cell death ensues. Therefore, they have great implications in the initiation and progression of numerous diseases. Chemical instability of ROS limits its direct detection and the dynamics remain poorly studied. To study the ROS dynamics, the endogenous or exogenous redox-sensitive fluorophores provide a good chance to detect the real-time changes in in vivo or in vitro settings. Here these methods are reviewed and their potential applications are discussed.

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