IMR Press / FBS / Volume 1 / Issue 1 / DOI: 10.2741/S12

Frontiers in Bioscience-Scholar (FBS) is published by IMR Press from Volume 13 Issue 1 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

The role of FGF-2 in renal fibrogenesis
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1 Department of Nephrology and Rheumatology, Georg-August-University Medical Center, Gottingen, Germany

*Author to whom correspondence should be addressed.


Front. Biosci. (Schol Ed) 2009, 1(1), 125–131;
Published: 1 June 2009

Basic fibroblast growth factor (FGF-2) is a pleiotropic cytokine which exerts its effects via four different high affinity receptors (FGFR-1 to -4) which function as protein tyrosine kinases. In the kidney, FGF-2 is expressed in epithelial cells already during fetal development. During later stages, expression of the cytokine can be found in distal tubular epithelial cells, glomerular cells and few interstitial cells. Expression in fibroblasts is robustly upregulated in chronic kidney scarring pointing to an important role in fibrogenesis. Functional studies have demonstrated that FGF-2 exerts mainly proliferative effects on a variety of renal cell types. In regard to fibrogenesis, the expression and induction of proliferation in interstitial fibroblasts may be the most important function. FGF-2 is one of the key factors contributing to autocrine fibroblast proliferation in post-inflammatory matrix synthesis. In addition, FGF-2 facilitates epithelial to mesenchymal transition of tubular epithelial cells contributing early to an increase of matrix producing cells. However, the cytokine does not contribute directly to extracellular matrix synthesis. Still, many aspects of FGF-2 in renal fibrogenesis remains to be evaluated.

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