IMR Press / FBL / Volume 9 / Issue 5 / DOI: 10.2741/1448

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Isoflavones in breast cancer chemoprevention: where do we go from here?
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1 Departments of Nutrition, University of South Florida, University of South Florida College of Medicine, Tampa, Florida
2 Departments of Drug Discovery, University of South Florida, University of South Florida College of Medicine, Tampa, Florida
3 Departments of Digital Imaging and Cancer Control, H. Lee Moffitt Cancer Center & Research Institute, University of South Florida, University of South Florida College of Medicine, Tampa, Florida
Academic Editor:Q. Ping Dou
Front. Biosci. (Landmark Ed) 2004, 9(5), 2927–2934; https://doi.org/10.2741/1448
Published: 1 September 2004
(This article belongs to the Special Issue Potential molecular targets for chemoprevention)
Abstract

Based on the evidence from epidemiological, animal, in vitro data and human clinical trials, it is evident that isoflavones are promising agents for breast cancer chemoprevention. It is also evident that the form of isoflavone used (purified vs soy products), dose of isoflavone used (low vs high), timing and duration of exposure of isoflavones appears to play a major role in determining agonistic or antagonistic effects. Collectively, these isoflavones have enough evidence to warrant use in a number of clinical trials to examine its efficacy as a potential chemopreventive agent for breast cancer. In this comprehensive review, we attempt to summarize the evidence demonstrating the potential use of isoflavones in breast cancer chemoprevention and the rationale to examine a combination of biochemical, morphological and molecular intermediate endpoint biomarkers of breast cancer risk to examine the efficacy of this promising agent.

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