IMR Press / FBL / Volume 9 / Issue 4 / DOI: 10.2741/1407

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Passive immunization for immunocontraception: lessons learned from infectious diseases
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1 Division of Research, Department of Obstetrics and Gynecology, Health education Building, Rm. 211, Medical College of Ohio, 3055 Arlington Ave, Toledo, OH 43614-5806, USA
Front. Biosci. (Landmark Ed) 2004, 9(4), 2457–2465;
Published: 1 September 2004

Development of vaccine for contraception is an exciting proposition that could provide a valuable alternative to the presently available methods for birth control. Various targets such as gonadotropin releasing hormone (GnRH), follicle stimulating hormone (FSH), leutinizing hormone (LH), zona pellucida (ZP) antigens, sperm antigens, and human chorionic gonadotropin (hCG) are being explored for immunocontraception. Besides specific concerns associated with each contraceptive vaccine, the progress has been restricted by the variability of the immune response after active immunization, attain and maintain high antibody titers, time lag to achieve reasonably good antibody titers, and uncertainty regarding how long the bioeffective antibodies will remain in circulation. It is envisaged that these concerns may be taken care of by using the preformed antibodies in the passive immunization approach. The antibody therapies have been tried and found to be successful against various infectious diseases both in animals as well as humans. Some have become treatment modalities in the clinics. This manuscript will review the data available for the passive immunization of preformed polyclonal and murine/humanized/human monoclonal antibodies, their efficacy, mode of delivery, duration of the effects, and limitations, if any. The overall objective is to examine the feasibility and practicability of the passive immunization approach for immunocontraception.

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