IMR Press / FBL / Volume 9 / Issue 4 / DOI: 10.2741/1404

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Functional role of acetylcholine in the immune system
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1 Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan
Academic Editor:Sergei Grando
Front. Biosci. (Landmark Ed) 2004, 9(4), 2414–2419;
Published: 1 September 2004
(This article belongs to the Special Issue Nonneuronal acetylcholine in normal physiology and pathology)

Increasing evidence indicates that the central nervous system (CNS) can operate certain immune functions. There is a bidirectional regulation system between the brain and peripheral immune system during infection and inflammation. Furthermore, autopsy brain preparations in Alzheimer's disease patients show the up-regulated expression of proinflammatory cytokines, suggesting an important role of cytokines in disease progression. Recently, acetylcholine has been suggested to inhibit lipopolysaccharide (LPS)- induced inflammation in macrophages. In this paper, we review the important aspects of several cytokines under the pathologic conditions of CNS. Furthermore, we discuss recent views on the nonneuronal action of acetylcholine in the cross talk between acetylcholine and the immune system.

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