IMR Press / FBL / Volume 9 / Issue 3 / DOI: 10.2741/1401

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Mechanisms of HTLV-1 transformation
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1 Department of Biochemistry and Molecular Biology, School of Medicine and Health Sciences, The George Washington University, Washington DC, 20037, USA
2 Department of Microbiology and Tropical Medicine, School of Medicine and Health Sciences, The George Washington University, Washington DC 20037, USA
3 The Institute for Genomic Research (TIGR), Rockville, MD 20850, USA
Academic Editor:Kenneth Roebuck
Front. Biosci. (Landmark Ed) 2004, 9(3), 2347–2372; https://doi.org/10.2741/1401
Published: 1 September 2004
(This article belongs to the Special Issue Inflammatory response mechanisms)
Abstract

HTLV-1 is the etiological agent of the fatal disease adult T-cell leukemia. The virus encodes many proteins including several accessory proteins, p12I, p13II, p27I, and p30II, whose roles have recently begun to be elucidated. These accessory proteins are important in T-cell activation, transcriptional regulation, viral persistence, and virus assembly. The viral oncogene Tax is thought to be largely responsible for tumorigenesis, although the precise mechanisms underlying transformation are not completely understood. Tax has a profound impact on transcription, cell growth regulation, genomic stability and apoptosis. This review will provide possible contributions of the accessory proteins to transformation as well as highlight the alterations of the above-mentioned cellular events by Tax. Animal models of both Tax and the accessory proteins are also included based on the essential information on the transformation process in vivo that they provide.

Keywords
HTLV-1
Oncogenesis
Tax
ATL
Cell Cycle
Transcription
Accessory Proteins
Apoptosis
Review
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