IMR Press / FBL / Volume 9 / Issue 3 / DOI: 10.2741/1335

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Oxygen free radical and antioxidant defense mechanism in cancer
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1 Centro de Investigaciones Biomédicas, ICBP “Victoria de Girón”
2 Centro para las Investigaciones y Evaluaciones Biológicas, Instituto de Farmacia y Alimentos, Universidad de la Habana, CUBA
3 Department of Chemistry and Medical Biochemistry, University of Milan, Via Saldini, 50-20133 Milan, Italy
Front. Biosci. (Landmark Ed) 2004, 9(3), 2029–2044;
Published: 1 September 2004

The reactive oxygen species (ROS) can damage the nucleic acids. The oxidative modification of the DNA constitutes the fundamental molecular event in carcinogenesis and that is why the interest in the study of the involvement of ROS in that process. On the other hand, oxidative DNA damage-induced mutagenesis is widely hypothesized to be a frequent event in the normal human cell. The enormous evidence suggests an important role of ROS in the expansion and progression of tumor clones, being considered a relevant class of carcinogens. In addition, the use of immunohistochemical techniques has showed that the various types of cancer examined to date manifest an imbalance in their antioxidant mechanisms to respect the primary cell. In the near future new insights in cancer therapies, based on modulation of cellular redox status, may lead the way to additional tools against carcinogenesis from ROS.

Reactive Oxygen Species
Oxidative damage to DNA
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