IMR Press / FBL / Volume 9 / Issue 2 / DOI: 10.2741/1298

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

The role of oxidative damage in mitochondria during aging: a review
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1 Center for Demographic Studies, Duke University, 2117 Campus Drive Box 90408, Durham, NC 27708, USA
Academic Editor:Kenneth Manton
Front. Biosci. (Landmark Ed) 2004, 9(2), 1100–1117;
Published: 1 May 2004
(This article belongs to the Special Issue Bio-demographic effects of genome-proteome interactions)

Aging is a complex process (or series of processes). Recent evidence suggests that several of its most important mechanisms are linked by means of cellular damage caused by reactive oxygen species (ROS). Oxidative damage may be a major factor in the loss of physiological functions that occur in degenerative diseases and aging. This is because, in aerobic organisms, the mitochondrial electron transport chain plays an important role in energy production and is a significant source of ROS that damage DNA, RNA, and proteins in cells. While oxidative events in other cell organelles are likely to contribute to the pathobiology of aging, this review highlights alterations in mitochondrial function that, due to accumulated oxidative damage, occur with age.

Oxidative damage
Free radicals
Reactive oxygen species
Mitochondrial DNA
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