IMR Press / FBL / Volume 9 / Issue 2 / DOI: 10.2741/1260

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Multiparametric effect: concentration analyses
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1 Department of Pediatric Transplantation, Children's Hospital of Pittsburgh, and the University of Pittsburgh, Pittsburgh, PA 15213, USA
Academic Editor:Rakesh Sindhi
Front. Biosci. (Landmark Ed) 2004, 9(2), 1218–1221; https://doi.org/10.2741/1260
Published: 1 May 2004
(This article belongs to the Special Issue Immunemodulation and immunosuppressants)
Abstract

Immunosuppressant drug toxicity currently competes with acute rejection, as the major cause of efficacy failure of potent new agents in clinical transplantation. The development of mechanistic drug targets as surrogate endpoints for use in the clinic has been facilitated by fluorescent imaging techniques which measure multiple cytokines and cell surface receptors on stimulated (peripheral blood) lymphocyte responses. However, the promise of delivering customized drug therapy to the transplant recipient remains unfulfilled. In this brief review, computational algorithms that can relate multiparametric effects to clinical drug concentrations of immunosuppressants are discussed. Based on Hill equations, these pharmacodynamic modeling techniques have been used to simulate single-agent effects, combination regimen effects, as well as the individual response to combination regimens. The potential implications of these models crystallize the clinical challenges confronting practitioners of clinical, post-transplant immunosuppression.

Keywords
Pharmacodynamic
Transplantation
T-cell
Bcell
Immunosuppression
Review
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