IMR Press / FBL / Volume 9 / Issue 2 / DOI: 10.2741/1239

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Regulation of endothelial cell function BY FAK and PYK2
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1 Cardiovascular Research Center, University of Virginia, Charlottesville, VA 22908
2 Cell Adhesion and Matrix Research Center and Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294-0019
Academic Editor:Candece Gladson
Front. Biosci. (Landmark Ed) 2004, 9(2), 1254–1266;
Published: 1 May 2004
(This article belongs to the Special Issue FAK family kinases in disease)

Endothelial cells form a continuous single layer lining throughout the vascular tree. Such positioning allows the endothelium to monitor numerous environmental signals within the blood vessel, including blood composition, structural matrix, and blood flow dynamics. Following signal integration, endothelial cells then induce context-specific changes in vessel properties. The nonreceptor tyrosine kinases focal adhesion kinase (FAK) and proline-rich tyrosine kinase-2 (Pyk2) are activated by integrins, growth factors, and mechanical stimuli, suggesting a potentially important role in the integration of environmental stimuli. This review will explore the current understanding of FAK and Pyk2 signaling in endothelial regulation of vascular function.

Focal Adhesion Kinase
Proline-Rich Tyrosine Kinase-2
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