IMR Press / FBL / Volume 9 / Issue 1 / DOI: 10.2741/1309

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Wnt signaling in B and T lymphocytes
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1 Laboratory of Cellular and Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
Academic Editor:Craig Malbon
Front. Biosci. (Landmark Ed) 2004, 9(1), 1000–1010; https://doi.org/10.2741/1309
Published: 1 January 2004
(This article belongs to the Special Issue Wnt-frizzled signaling in development)
Abstract

Wnt signaling has been shown to be critical for proper embryonic development as well as growth regulation of certain adult tissues. Defects in Wnt pathways have additionally been associated with a number of human cancers. However, it is only recently that a role for Wnts in the immune system has come to be appreciated. Wnts have now been shown to play significant roles in early stage development of both B and T lineage cells. Current studies suggest that proliferation and/or survival of these cells is associated with activation of the 'canonical' Wnt/beta-catenin pathway. Functional Wnt signaling appears to also occur in end stage B (plasma) cells where both the 'canonical' and the Wnt/RhoA pathways are activated. Herein, we review the current understanding of Wnt signaling in B and T cell development and the potential involvement of Wnt cascades in lymphoid neoplasia.

Keywords
Signal Transduction
Wnt
beta catenin
B cell
T cell
Review
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