IMR Press / FBL / Volume 9 / Issue 1 / DOI: 10.2741/1278

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

B cells in multiple sclerosis
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1 Departments of Neurology, University of Colorado Health Sciences Center, Denver, CO 80262
2 Departments of Microbiology, University of Colorado Health Sciences Center, Denver, CO 80262
Academic Editor:Alireza Minagar
Front. Biosci. (Landmark Ed) 2004, 9(1), 786–796;
Published: 1 January 2004
(This article belongs to the Special Issue Inflammatory disorders of the nervous system)

The most common laboratory abnormality in multiple sclerosis (MS) is an increased amount of cerebrospinal fluid IgG and the presence of oligoclonal bands. Despite studies of the humoral response that suggest the involvement of an infectious agent or autoantigen in disease, the major targets of the oligoclonal response are still unknown. Identification of these targets will reveal valuable insights into the cause and pathogenesis of MS and is likely to lead to effective treatment.

Multiple Sclerosis
B cells
Oligoclonal Bands
Central Nervious System
Neurologic Disease
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