IMR Press / FBL / Volume 9 / Issue 1 / DOI: 10.2741/1235

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Feline immunodeficiency virus: a concise review
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1 Federal University of Amapa, Departament of Microbiology, Rodovia Juscelino Kubtscheck de Oliveira, Km 02. Macapa, Amapa.Brazil.CEP 68902-280, Brasil
2 San Diego VA Healthcare System, Infectious Disease 9-111F, 3350 La Jolla Village Drive, San Diego, CA 92161
3 University of California, San Diego. Departament of Medicine, 0678, La Jolla, CA 92093-0678
Front. Biosci. (Landmark Ed) 2004, 9(1), 370–377;
Published: 1 January 2004

Among non-primate vertebrates, feline immunodeficiency virus (FIV) infection in the cat may be the closest model of human immunodeficiency virus (HIV) infection and acquired immunodeficiency syndrome (AIDS). Clinical evolution and immunological and virological relationships between human HIV/AIDS and disease produced by FIV infection in cats are very close. These similarities should facilitate progress in the understanding of mechanisms of viral infection and immunopathology, and make this model potentially very valuable in evaluation of experimental therapeutic approaches to AIDS in man. Development of feline immunodeficiency virus vectors bearing therapeutic genes targeting different human diseases is a promising strategy for gene therapy, despite some recent studies which suggest that despite lack of evidence of infection of man by FIV, additional epidemiological surveillance may be indicated to determine if transmission can occur from this close companion to humans in some circumstances.

Feline Immunodeficiency Virus
Human Immunodeficiency Virus
Animal models
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