IMR Press / FBL / Volume 9 / Issue 1 / DOI: 10.2741/1210

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
EGF family of growth factors: essential roles and functional redundancy in the nerve system
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1 Department of Orthopaedic Surgery, Women’s and Children’s Hospital, Adelaide, Australia
2 Department of Human Physiology, Flinders University, Adelaide, Australia
Academic Editor:John Leah
Front. Biosci. (Landmark Ed) 2004, 9(1), 85–92; https://doi.org/10.2741/1210
Published: 1 January 2004
(This article belongs to the Special Issue Regulation of gene expression in the brain)
Abstract

Evidence has suggested that the epidermal growth factor receptor (EGF-R) and its ligands are important regulators for development and maintenance of various tissues including the nerve system. Gene knockout, transgenic or other in vivo and in vitro studies have demonstrated that these molecules, produced by neurons and glial cells, play important roles in regulating neural/glial precursor cell or stem cell proliferation, migration, differentiation and survival, in maintaining tissue homeostasis, and in regulating CNS gliosis and peripheral nerve injury responses. These studies have revealed that, despite a possible functional redundancy among the individual EGF family ligands, collectively EGF-R ligands are required for development and maintenance of the nerve system.

Keywords
TGF-alpha
HB-EGF
EGF Receptor
Brain
Nervous System
Proliferation
Migration
Differentiation
Survival
Development
Injury
Gene Knockout
Transgenic
Expression
Redundancy
Review
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