IMR Press / FBL / Volume 9 / Issue 1 / DOI: 10.2741/1198

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Cellular-resolution activity mapping of the brain using immediate-early gene expression
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1 Department of Psychology, McGill University, Montreal, Canada
Front. Biosci. (Landmark Ed) 2004, 9(1), 104–109;
Published: 1 January 2004

Immediate-Early Genes are a class of genes that are rapidly up-regulated following neural stimulation. Due to their quality as potential activity markers in the CNS, they have been used extensively in functional mapping studies. At least three genes have been popularly used, including zif268 (Egr1, NGFI, Krox-24, or ZENK), c-fos and recently, Arc. A number of techniques have been developed in applying IEG labelling for the development of functional maps, thus overcoming some of the earlier limitations of this approach. Current developments highlight the future prospects of cellular-resolution functional activity mapping of the brain.

Immediate-Early Genes
Molecular Mapping
Neural Activity
gene expression
dual activity mapping. c-fos
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