IMR Press / FBL / Volume 8 / Issue 6 / DOI: 10.2741/962

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article

Human viral cardiomyopathy

Show Less
1 Department of Internal Medicine-Cardiology, Philipps-University Marburg, Germany
2 University Institute for Cardiovascular Diseases, Medical Center of Serbia, Belgrade, Yugoslavia

Academic Editor: Herbert B. Tanowitz

Front. Biosci. (Landmark Ed) 2003, 8(6), 39–67; https://doi.org/10.2741/962
Published: 1 January 2003
(This article belongs to the Special Issue Infectious diseases of the myocardium)
Abstract

Viral infection of the heart is relatively common, usually asymptomatic and has a spontaneous and complete resolution. It can, however, in rare cases, lead to substantial cardiac damage, development of viral cardiomyopathy and congestive heart failure. Viral cardiomyopathy is defined as viral persistence in a dilated heart. It may be accompanied by myocardial inflammation and then termed inflammatory viral cardiomyopathy (or viral myocarditis with cardiomegaly). If no inflammation is observed in the biopsy of a dilated heart (<14 lymphocytes and macrophages/mm2) the term viral cardiomyopathy or viral persistence in dilated cardiomyopathy should be applied. The diagnosis of myocarditis and viral cardiomyopathy can be made only by endomyocardial biopsy, implementing the WHO/WHF criteria, and PCR techniques for identification of viral genome. The most frequent cardiotropic viruses detected by endomyocardial biopsy are Parvo B19, enteroviruses, adenoviruses, cytomegalovirus, and less frequently Epstein-Barr virus, and influenza virus.

Keywords
Myocarditis
Cardiomyopathy
Viruses
Review
Share
Back to top