IMR Press / FBL / Volume 8 / Issue 6 / DOI: 10.2741/935

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Replication of lentiviruses
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1 The Dorrance H. Hamilton Laboratories, Center for Human Virology, Division of Infectious Diseases, Department of Medicine, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA

Academic Editors: Roger Pomerantz, Ralph Dornburg

Front. Biosci. (Landmark Ed) 2003, 8(6), 156–174;
Published: 1 January 2003
(This article belongs to the Special Issue Engineered retroviruses)

Lentiviruses belong to a subfamily of the retroviruses usually associated with persistent infections in animals and humans. They have complex replication cycles involving numerous regulatory and accessory proteins, which sets them apart from the oncoretroviruses and spumaviruses, the two other main subfamilies of the retroviruses. Studies over the years have elucidated the various molecular mechanisms involved in the replication of lentiviruses. The first step involves the fusion of the envelope glycoprotein (gp120) to the host cell membrane followed by entry of the virus into the host cell. Immediately following viral entry is reverse transcription, integration, gene expression, encapsidation, budding and lastly virus maturation. This review focuses on the molecular mechanisms involved in the lentiviral replication, using human immunodeficiency virus type I (HIV-1) as an example.

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