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Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.
BRCA proteins and DNA damage checkpoints
Zhenkun Lou1, Junjie Chen1,*
1 Department of Oncology, Mayo Clinic, Rochester, MN 55905, USA
Academic Editor: Wei Dai
Front. Biosci. (Landmark Ed) 2003, 8(6), 718–721; https://doi.org/10.2741/1127
Published: 1 May 2003
(This article belongs to the Special Issue Cell cycle checkpoint control)
BRCA1 and BRCA2 are frequently mutated in breast cancer patients, responsible for the majority cases of familial breast cancer. Through genetic and biochemical analysis, the function of BRCA1 and BRCA2 is emerging. This review examines recent progresses in understanding the roles of BRCA proteins in DNA damage checkpoint control and how they are regulated in response to DNA damage.