IMR Press / FBL / Volume 8 / Issue 6 / DOI: 10.2741/1116

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Roles of FAK family kinases in nervous system
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1 Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
2 Department of Neurobiology , University of Alabama at Birmingham, Birmingham, AL 35294

Academic Editor: Candece Gladson

Front. Biosci. (Landmark Ed) 2003, 8(6), 676–682;
Published: 1 May 2003
(This article belongs to the Special Issue FAK family kinases in disease)

Focal adhesion kinase (FAK) and its related kinase, proline rich tyrosine kinase 2 (PYK2), are major kinases activated by cell-extracellular matrix adhesion. Although they are highly expressed in the nervous system, the functions of these two kinases in the nervous system remained unclear until recently. FAK and PYK2 appear to play an important role in developing nervous system as well as adult brain. Importantly the two kinases are activated by different extracellular stimuli and execute distinct regulatory effects on various aspects of neural developmental processes and neuronal function. This review summarizes the potential roles of FAK and PYK2 in axon path-finding and synaptic plasticity.

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