IMR Press / FBL / Volume 8 / Issue 6 / DOI: 10.2741/1075

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

On the mechanism of solute uptake in Pseudomonas
Show Less
1 Department of Microbiology and Immunology, University of British Columbia, #300 6174 University Boulevard, Vancouver, BC, Canada V6T 1Z3
Front. Biosci. (Landmark Ed) 2003, 8(6), 472–483;
Published: 1 May 2003

Pseudomonas species have over 300 known and putative nutrient uptake systems enabling them to metabolize a large number of organic compounds, and thus inhabit many diverse ecological niches. The outer membrane of these organisms acts as a semi-permeable barrier, excluding many classes of potentially toxic molecules from the cell. Nutrients use specialized water-filled channels called porins to traverse this barrier. Entry into the cell is mediated by one of four classes of cytoplasmic membrane transporters: glycerol facilitators, phosphotransferase systems, primary active transporters, and secondary active transporters. The class of transporter used is dependent on the environmental conditions, as well as the type and concentration of solute. The recent advances in elucidating the structures and functional mechanisms of these uptake systems will be discussed in this review.

Back to top