IMR Press / FBL / Volume 8 / Issue 6 / DOI: 10.2741/1064

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Mathematical models of sleep regulation
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1 Institute of Pharmacology and Toxicology, University of Zurich, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland
Front. Biosci. (Landmark Ed) 2003, 8(6), 683–693;
Published: 1 May 2003

The level of EEG slow-wave activity (SWA) is determined by the duration of prior sleep and waking. SWA is a marker of nonREM sleep intensity and may serve as an indicator of sleep homeostasis. The two-process model of sleep regulation posits the interaction of the homeostatic Process S and the circadian Process C. Also models of neurobehavioral functions (three-process model; interactive models of alertness and cognitive throughput) are based on the concept of an interaction between homeostatic and circadian factors. Whether the interaction is linear or non-linear is still unresolved. Models may serve as a guiding principle for specifying the relationship between processes occurring at the macroscopic and microscopic level of analysis.

Circadian Process
Homeostatic Process
Mathematical Models
TwoProcess Model
Slow-Wave Activity
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