IMR Press / FBL / Volume 8 / Issue 5 / DOI: 10.2741/979

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Cytokines and chemokines in allergic bronchopulmonary aspergillosis (ABPA) and experimental Aspergillus-induced allergic airway or asthmatic disease
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1 Department of Pathology, University of Michigan Medical School, 1301 Catherine Road, Ann Arbor, MI 48109-0602, USA

Academic Editor: Viswanath Kurup

Front. Biosci. (Landmark Ed) 2003, 8(5), 147–156;
Published: 1 January 2003
(This article belongs to the Special Issue Allergic aspergillosis)

Allergic bronchopulmonary aspergillosis (ABPA) is a devastating clinical disease that results from an aggressive pulmonary allergic response to the antigens released by colonizing Aspergillus fumigatus (A. fumigatus) in the respiratory system. Many of the allergic features of clinical ABPA have been reproduced in murine models, thereby facilitating a detailed analysis of the inflammatory and immune events that surround the initiation and maintenance of this disease. Herein, we describe the involvement of cytokines and chemokines in murine allergic pulmonary disease elicited by A. fumigatus antigens and spores (or conidia). More importantly, data derived from murine models of Aspergillus-induced allergic airway disease or asthma also suggest that the specific targeting of cytokines and/or chemokines may provide a novel therapeutic strategy in the treatment of clinical ABPA.

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