IMR Press / FBL / Volume 8 / Issue 5 / DOI: 10.2741/1091

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.


Hepatolithiasis—epidemiology and pathogenesis update

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1 Department of Gastroenterology, Institute of Clinical Medicine, The University of Tsukuba, 1-1-1 Tennodai, Tsukuba-shi, Ibaraki 305-8575, Japan
2 Aikawa Hospital, Daihata, Senba, Mito-shi, Ibaraki 310-0851, Japan
Front. Biosci. (Landmark Ed) 2003, 8(5), 398–409;
Published: 1 May 2003

Hepatolithiasis or intrahepatic calculi are prevalent in East Asia, including Japan, but occurs much less frequently in Western countries. Hepatolithiasis appears mostly as brown pigment stones (calcium bilirubinate stones) but contain more cholesterol in composition. The disease is characterized by its intractable nature and frequent recurrence, requiring multiple operative interventions, in distinct contrast to gallbladder cholesterol or black pigment stones. Moreover, the most unfavorable complication of the disease is an intrahepatic cholangiocarcinoma. In view of the lack of information on the pathogenesis, a multidisciplinary approach has been carried out through the Hepatolithiasis Research Group organized by the Ministry of Health and Welfare of Japan. In this review, the up-to-date data on the epidemiology and pathogenesis of hepatolithiasis are introduced and discussed. Furthermore, potential medical treatments targeting pathogenetic molecules, which may be important for the etiological process of gallstone formation, are introduced as future therapeutic options for the disease.

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