IMR Press / FBL / Volume 8 / Issue 4 / DOI: 10.2741/1132

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Solute uptake through general porins
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1 Department of Biology & Biochemistry, University of Houston, 369 Science Research Building 2, Houston, TX 77204-5001, USA

Academic Editor: Phillip Klebba

Front. Biosci. (Landmark Ed) 2003, 8(4), 1055–1071;
Published: 1 May 2003
(This article belongs to the Special Issue Bacterial membrane transport)

General diffusion porins are among the few membrane proteins that have been thoroughly investigated by many techniques, including X-ray crystallography, AFM microscopy, computer modeling, electrophysiology and biochemistry. This had led to a good understanding of the process of solute transport per se. However, other aspects of porin function remain enigmatic, such as the molecular basis and physiological relevance of many regulatory processes. After summarizing the most salient structural features, the review provides a description of the techniques used for the functional study of porins. The process of solute transport is presented on the basis of structure-function relationship and modeling studies. Three aspects of regulation are discussed: voltage-dependence, pH sensitivity and modulation by polycations and polyanions. The review ends with a perspective on future porin research, to be targeted at a molecular understanding of the regulatory processes, the deciphering of the physiological context in which these processes take place, and rational drug design.

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