IMR Press / FBL / Volume 8 / Issue 4 / DOI: 10.2741/1102

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Osteoclasts, pro-inflammatory cytokines, RANK-L and bone remodeling in rheumatoid arthritis
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1 Department of Immunology/Microbiology, Rush-Presbyterian-St. Luke's Medical Cente, Chicago, IL 60612, USA
2 Department of Medicine, Section of Rheumatology, Rush-Presbyterian-St. Luke’s Medical Cente, Chicago, IL 60612 USA

Academic Editor: Kenneth Roebuck

Front. Biosci. (Landmark Ed) 2003, 8(4), 1018–1029;
Published: 1 May 2003
(This article belongs to the Special Issue Inflammatory response mechanisms)

Inflammatory joint diseases such as rheumatoid arthritis tend to destroy joint cartilage and bone matrices. Since bone resorption is a common characteristic of rheumatoid arthritis, one of the cell types thought to play a vital role in the destruction of these matrices are the osteoclasts. Osteoclasts and osteoclastogenic factors such as inflammatory cytokines and RANK-L are present within inflamed joints, and osteoclastic bone resorptive activities are also displayed, further suggesting the possibility that osteoclasts are responsible for the joint cartilage and bone matrix damage observed in this joint disease.

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