IMR Press / FBL / Volume 8 / Issue 4 / DOI: 10.2741/1097

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Function of bone morphogenetic protein signaling during mouse development
Show Less
1 Molecular Developmental Biology Section, Laboratory of Reproductive and Developmental Toxycology, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709 USA

Academic Editor: Di Chen

Front. Biosci. (Landmark Ed) 2003, 8(4), 855–869;
Published: 1 May 2003
(This article belongs to the Special Issue TGFbeta,BMP receptor signaling)

Bone morphogenetic proteins (BMPs) play pleiotropic roles during development and after birth in many different organisms. BMPs are members of TGF-beta superfamily. There are more than 20 members with three type II receptors and three type I receptors. Genetic approaches using the mouse as a model system revealed many of the functions of BMPs. Particularly, results obtained through loss-of-function analyses of BMP ligands and their receptors are reviewed in this article.

Back to top