IMR Press / FBL / Volume 8 / Issue 4 / DOI: 10.2741/1052

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article

Snares for GLUT4 – mechanisms directing vesicular trafficking of GLUT4

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1 CSIRO Health Science and Nutrition, 343 Royal Parade, Parkville, Australia 3052

Academic Editor: Konstantin Kandror

Front. Biosci. (Landmark Ed) 2003, 8(4), 620–641; https://doi.org/10.2741/1052
Published: 1 May 2003
(This article belongs to the Special Issue Insulin regulation of glucose transport)
Abstract

Fusion of GLUT4 vesicles with the plasma membrane is a key terminal step in insulin-regulated glucose transport. This fusion event is mediated by SNARE proteins, syntaxin 4, SNAP23 and VAMP2, through a process regulated by accessory proteins whose roles are still unclear. Munc18c is a key regulatory protein of syntaxin, and possibly of whole-SNARE complex cycling. Rab GTPases, through interactions with tethering molecules and SNAREs, provide targeting specificity in the GLUT4 secretory pathway. We review here insulin-mediated signaling of glucose transport, and particularly the role played by SNAREs and their accessory proteins.

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