IMR Press / FBL / Volume 7 / Issue 4 / DOI: 10.2741/rider

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Progesterone and the control of uterine cell proliferation and differentiation
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1 Department of Biology, Pittsburg State University, 1701 South Broadway, Pittsburg, Kansas 66762, USA
Academic Editor:William Okulicz
Front. Biosci. (Landmark Ed) 2002, 7(4), 1545–1555; https://doi.org/10.2741/rider
Published: 1 June 2002
(This article belongs to the Special Issue Progesterone action and the endometrium)
Abstract

Progesterone is the only steroid hormone that is essential for the establishment and maintenance of pregnancy in all mammalian species that have been studied. Mice lacking the progesterone receptor (PR) by targeted mutagenesis exhibit abnormalities in all aspects of reproduction including sexual behavior, mammary gland development, ovulation, and implantation. Implantation in PR null mice fails, in part, because the uterine stromal cells cannot undergo differentiation (the decidual cell reaction). Uterine stromal cells do not divide without progesterone and proliferation is blocked by progesterone antibodies and PR antagonism. In spite of the preeminence of progesterone in female reproduction, its molecular mechanisms of action on target cell proliferation and differentiation are not well understood. Recent studies suggest that progesterone plays a direct role in regulating cell cycle transit by increasing the expression and activation of cell cycle regulatory complexes. Furthermore, this progesterone-dependent regulation of cell cycle transit may provide a unique window of opportunity for uterine stromal cells to exit the proliferative cycle, and if exposed to appropriate agents, enter into the differentiation pathway.

Keywords
Uterus
Cell Proliferation
Progesterone
Cell Cycle
Cell Differentiation
Review
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