IMR Press / FBL / Volume 7 / Issue 4 / DOI: 10.2741/racke

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Control of myeloid dendritic cell differentiation and function by CD1d-restricted (NK) T cells
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1 Department of Pathology, Johns Hopkins University, Baltimore, MD 21287, USA
2 Department of Pathology, College of Medicine, University of Florida, Gainesville, Floridaa 32610, USA
3 Cancer Immunology & AIDS, Dana Farber Cancer Institute, 44 Binney Street, Boston, MA 02115, USA
Academic Editor:Adam Goldfarb
Front. Biosci. (Landmark Ed) 2002, 7(4), 978–985; https://doi.org/10.2741/racke
Published: 1 April 2002
(This article belongs to the Special Issue Topics in molecular hematology)
Abstract

While regulating a wide variety of immunologic responses, the precise immunologic functions of CD1d-restricted (NK) T cells are not well defined. Notably, In vitro activation of human NK T cell clones results in the secretion of multiple cytokines important for the recruitment and differentiation of myeloid dendritic cells (DC). Once differentiated, these DC strongly activate NK T cells. In humans, CD1d is expressed by myeloid DC and on tumor cells of this lineage. Another specialized myeloid antigen presenting cell, the epithelioid histiocyte seen in granulomatous inflammation, also expresses CD1d. Because myeloid DC are important regulators of Th1/Th2 T cell responses, cross talk between human NK T cells and myeloid DC would be expected to have significant impact on many immune responses. Consistent with this hypothesis, NK T cells are required for myeloid DC-controlled antitumor responses in mice, and regulate diabetes in nonobese diabetic (NOD) mouse by locally controlling the frequency and function of DC subsets. Thus, regulation of myeloid DC by NK T cells controls both the transition from innate to adaptive immunity and the Th-phenotype of subsequent T cell responses.

Keywords
Dendritic Cells
Myeloid
Nk T Cells
Autoimmunity
Diabetes
Th Phenotype
Antigen Presenting Cells
Cd1d
Cellular Immune Responses
Tumors
& Melanoma
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