IMR Press / FBL / Volume 7 / Issue 4 / DOI: 10.2741/mustelin

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Protein tyrosine phosphatases
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1 The Burnham Institute, La Jolla Cancer Research Center, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
Academic Editor:Alexander Tsygankov
Front. Biosci. (Landmark Ed) 2002, 7(4), 85–142; https://doi.org/10.2741/mustelin
Published: 1 January 2002
(This article belongs to the Special Issue Tyrosine protein phosphorylation in cell signaling)
Abstract

The molecular mechanisms of signal transduction have been at the focus of increasingly intense scientific research. As a result, our understanding of protein tyrosine kinase-mediated signaling has advanced at an unprecedented pace during the past decade. In contrast, the study of protein tyrosine phosphatases has lagged behind, but is now gathering momentum and is predicted to become a "hot topic" in the field within the next few years. This review summarizes the current state-of-the art in our understanding of the structure, regulation and role of protein tyrosine phosphatases with emphasis on the lymphocyte system.

Keywords
Review
Phosphatases
PTPases
HePTP
STEP
PCPTP
PTP1B
TCPTP
SHP1
SHP2
PEP
PTPPEST
PTP-HSCF
PTP-MEG2
PTPH1
PTP-MEG1
FAP-1
PTP-BAS
PTP36
VHR
Pac-1
MKP-1
MKP-2
MKP-3
MKP-4
MKP-X
B23
hVH4
M3/6
PTEN
LMPTP
PRL-1
OV-1
PRL-2
PRL-3
Review
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