IMR Press / FBL / Volume 7 / Issue 4 / DOI: 10.2741/hatziva

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Cellular signaling pathways engaged by the Epstein-Barr virus transforming protein LMP1
Show Less
1 Department of Biology, Aristotle University of Thessaloniki, Thessaloniki 54006, Greece
2 Institute of Immunology, Biomedical Sciences Research Center Al. Fleming, 14-16 Al. Fleming Str., Vari 16672, Greece
Academic Editor:Erle Robertson
Front. Biosci. (Landmark Ed) 2002, 7(4), 319–329; https://doi.org/10.2741/hatziva
Published: 1 January 2002
(This article belongs to the Special Issue DNA viruses and human malignancies)
Abstract

The latent membrane protein 1 (LMP1) of Epstein-Barr virus (EBV) is an essential component of the viral machinery that orchestrates cellular transformation and oncogenesis. The critical role of LMP1 in transformation has been established through recombinant genetic analysis of the EBV genome, ectopic expression in cell lines and transgenic mice and immunohistochemical analysis of EBV- associated tumor specimens. The principal mechanism of LMP1 function is based on mimicry of activated cell surface receptors of the tumor necrosis factor superfamily. LMP1 signaling culminates in the activation of transcription factors NF-κB, AP1 and STAT1/3, which have been tightly linked to prevention of apoptosis and malignant transformation. The molecular mechanisms of LMP1 function will be reviewed in this report.

Keywords
Tumorigenesis
Lymphomas
Nasopharyngeal Carcinoma
Latent Membrane Protein 1
Tumor Necrosis Factor Receptor Associated Factors
NF-kB
AP-1
Review
Share
Back to top