IMR Press / FBL / Volume 7 / Issue 4 / DOI: 10.2741/hall

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Autoinhibition of Sos by intramolecular interactions
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1 Department of Molecular Genetics and Microbiology, State University of New York at Stony Brook, Stony Brook, New York 11794-5222, USA
2 The Graduate Programs in Molecular Pharmacology, State University of New York at Stony Brook, Stony Brook, New York 11794-5222, USA
3 Molecular and Cellular Biology, State University of New York at Stony Brook, Stony Brook, New York 11794-5222, USA
Academic Editor:Michael Miller
Front. Biosci. (Landmark Ed) 2002, 7(4), 288–294; https://doi.org/10.2741/hall
Published: 1 January 2002
(This article belongs to the Special Issue Autoinhibition in signal transduction proteins)
Abstract

Sos proteins function as activators of Ras signaling by catalyzing guanine nucleotide exchange on Ras. Sos regulation was initially thought to be accomplished primarily through its growth factor-dependent recruitment to the plasma membrane. More recent data has indicated that while membrane association is an indispensable means of Sos regulation, additional mechanisms involving intramolecular interactions function to control Sos activity towards Ras. This review will examine the experimental evidence for Sos intramolecular interactions and their contribution to Sos regulation.

Keywords
Ras
Sos
Autoinhibition
Receptor Tyrosine Kinase
Guanine Nucleotide Exchange
Intramolecular Interaction
Review
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