IMR Press / FBL / Volume 7 / Issue 4 / DOI: 10.2741/baluch

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Cellular scaffolds in mammalian eggs
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1 Department of Biology, Molecular and Cellular Biology Program, Arizona State University, Tempe, Arizona 85287-1501, USA
Academic Editor:David Capco
Front. Biosci. (Landmark Ed) 2002, 7(4), 1653–1661;
Published: 1 July 2002
(This article belongs to the Special Issue Molecular and biochemical control of preimplantation development)

Cellular scaffolds serve as structural components to which various elements of signal transduction pathways can be associated. The association of components on a scaffold can have several important functions, for example they can: 1) associate upstream regulatory components in a cascade that can increase the speed of response to a stimulus; 2) restrict access of substrates to enzymes associated with the scaffold; 3) permit cross talk between distinct signaling pathways, and; 4) aid in the establishment of cellular polarity. The conversion of the mammalian egg into the zygote requires many rapid alterations during a distinct time frame to mediate the biochemical and structural changes that occur. Cellular scaffolds provide a mechanism that can perform these rapid, highly orchestrated changes. They can permit interaction between distinct calcium-dependent pathways and also can provide a means for the calcium signal, that is initiated by fertilization, to act on calcium-independent pathways. This review considers various lines of evidence suggesting that in the mammalian egg, the meiotic spindle serves as a cellular scaffold that permits coordination among several signaling pathways essential for fertilization and the initiation of early development.

Spindle Apparatus
MAP kinase
Calcium/Calmodulin Dependent Protein Kinase II
protein kinase C
Signal Transduction
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