IMR Press / FBL / Volume 7 / Issue 4 / DOI: 10.2741/bagley

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Establishing immunological tolerance through the induction of molecular chimerism
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1 Transplantation Biology Research Center, Massachusetts General Hospital and Harvard Medical School, 149-5210 13th St., Boston, MA 02129, USA
Academic Editor:John Iacomini
Front. Biosci. (Landmark Ed) 2002, 7(4), 1331–1337;
Published: 1 May 2002
(This article belongs to the Special Issue Transplantation tolerance)

One of the major goals of transplantation biology is to overcome transplant rejection without the need for life-long immunosuppression. Over the last several years, fundamental advances in our understanding of the immune response to allogeneic and xenogeneic antigens have stimulated a great deal of interest in the possibility of using gene therapy approaches to overcome the host response leading to transplant rejection while alleviating the need for non-specific immunosuppression. Here, we review recent progress in the field on the use of gene therapy to induce transplantation tolerance to donor organs and tissues.

Gene Therapy
T cells
B cells
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