Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.
Splice variants of human β1 integrins: origin, biosynthesis and functions
The integrin β1 subfamily of adhesion receptors consists of 12 members and forms the biggest subfamily among integrins. Human integrin subunit beta1 has five cytoplasmic splice variants (β1A, β1B, β1C-1, β1-C2, β1D). Even though cytoplasmic splice variants do not change the ligand-specificity of a β1 integrin, clustering of these different splice variants triggers signaling pathways that lead to a different cellular response. The main focus of this review is on the origin and specific functions of the less abundant human integrin β1 splice variants (B, C-1, C-2, D).