IMR Press / FBL / Volume 7 / Issue 4 / DOI: 10.2741/A874

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Modulation of aromatase activity and expression by environmental chemicals
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1 Division of Immunology, Beckman Research Institute of the City of Hope, Duarte, CA 91010, USA
Academic Editor:Shiuan Chen
Front. Biosci. (Landmark Ed) 2002, 7(4), 1712–1719; https://doi.org/10.2741/A874
Published: 1 August 2002
(This article belongs to the Special Issue Endocrine disruptors)
Abstract

Aromatase is the enzyme that converts androgen to estrogen. Our laboratory has proposed and demonstrated that aromatase is an important target of some environmental chemicals. We have found that some of these compounds inhibit aromatase activity, resulting in a decrease in the level of estrogen or an increase in the level of androgen in cells. Environmental chemicals can also modify the expression of aromatase in various tissues, resulting in a change in the ratio between androgen to estrogen. The compounds that inhibit aromatase or suppress aromatase expression will behave as antiestrogens or androgen-like compounds in vivo. On the other hand, compounds that increase aromatase expression or enhance aromatase activity (or stability) may function as anti-androgens or estrogen-like compounds. This review will summarize and discuss findings from this and other laboratories on the effects of environmental chemicals on aromatase activity and expression.

Keywords
Aromatase
Endocrine Disruptors
Environmental Chemicals
Estrogen Receptor
Review
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