IMR Press / FBL / Volume 7 / Issue 4 / DOI: 10.2741/A769

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article

The role of plasma membrane Ca2+ pumps (PMCAs) in pathologies of mammalian cells

Show Less
1 Comenius University, Jessenius Medical Faculty, Department of Medical Biochemistry, Malá Hora 4, SK-03601 Martin, Slovakia
2 Laboratorium voor Fysiologie, K.U.Leuven, Campus Gasthuisberg, B-3000 LEUVEN, Belgium
Academic Editor:Emanuel Strehler
Front. Biosci. (Landmark Ed) 2002, 7(4), 53–84; https://doi.org/10.2741/A769
Published: 1 January 2002
(This article belongs to the Special Issue Calcium homeostasis and calcium signaling in health and disease)
Abstract

The biochemical function of the plasma membrane calcium ATPases (PMCAs) is the extrusion of cytosolic Ca2+ from the cell. Although this general function is well documented, the role of the complex isoform diversity and especially the contribution of specific isoforms to pathological conditions is less well understood. No human disease has been linked to a defect in any of the four PMCA genes. Nevertheless, isoforms do not have redundant functions, as shown by the indispensable role of PMCA2 demonstrated in transgenic mice. This review summarizes the results of recent analysis of the PMCA dysregulation in diseased cells or model systems of pathological conditions, including both acute disorders like hypoxia/ischemia and seizure, and slowly progressing dysfunctions like Alzheimer's disease, hypertension, diabetes and aging. Abnormalities in PMCA or its regulators have been described in various organs, reflected in changes of expression levels or in modifications or proteolysis of the PMCA protein. Changes of PMCA function are often detected in cell types different from the specific type involved in the pathology, pointing to more general defects. Examples are erythrocytes in diabetes and blood platelets in hypertension. The changes suggest the significance of PMCA in Ca2+ homeostasis both in excitable and non-excitable cells.

Keywords
Neurons
Muscle Cells
Ca2+ Transporting Epithelial Cells
Red Blood Cells
Liver
Kidney
Disorders
Ischemia
Oxidative Stress
Diabetes
Hypertension
Aging
Plasma Membrane Ca2+ Pump
Modification
Review
Share
Back to top