IMR Press / FBL / Volume 6 / Issue 5 / DOI: 10.2741/A716

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Pediatric stem cell transplantation and critical care (an outcome evaluation)
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1 Cardinal Glennon Children's Hospital, 1465 S. Grand, St. Louis, MO 63104, USA
Front. Biosci. (Landmark Ed) 2001, 6(5), 33–37;
Published: 1 August 2001

This paper reviews eight published studies of children who required critical care following a stem cell transplant. Approximately 14% of children required mechanical ventilation following stem cell transplant. Sixteen percent of these children survived. Eleven percent of children who had primary lung injury secondary to either infectious or non-infectious causes survived. Patients with respiratory failure induced by disease in organ systems other than the lungs had much better survival (33-39%). Children reported to have a non-bacterial infectious lung disease had very poor survival. Children who developed multi-organ system failure (MOSF) in addition to lung disease also had poor survival. The majority of children died of MOSF or pulmonary failure.

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