IMR Press / FBL / Volume 6 / Issue 3 / DOI: 10.2741/tomaras

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.


CD8+ T cell mediated noncytolytic inhibition of human immunodeficiency virus type I

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1 Department of Surgery, Center for AIDS Research, Duke University Medical Center, Durham, NC 27710, USA

Academic Editor: Adriana Heguy

Front. Biosci. (Landmark Ed) 2001, 6(3), 575–598;
Published: 1 March 2001
(This article belongs to the Special Issue New and emerging targets for antiviral therapy)

The development of cellular immune responses in primary human immunodeficiency virus type-1 (HIV-1) infection is accompanied by a dramatic decrease in plasma viremia and resolution of the acute clinical syndrome. The full nature of the immunological response and its consequences on HIV pathogenesis is still largely a mystery, but significant progress has been achieved in the characterization of some of the players involved. Several studies indicate that noncytolytic HIV suppression by CD8+ T lymphocytes may be inversely associated with viral load suggesting that this antiviral activity is important in host control of HIV replication. This review focuses on this antiviral activity by CD8+ T lymphocytes, which is distinct from that activity elicited by some cytolytic CD8+ T lymphocytes (CTLs).

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