IMR Press / FBL / Volume 6 / Issue 3 / DOI: 10.2741/superko

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Lipoprotein subclasses and atherosclerosis
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1 Berkeley HeartLab, Cholesterol, Genetics and Heart Disease Institute, 1875 South Grant St., San Mateo, CA 94402, USA

Academic Editor: David Hui

Front. Biosci. (Landmark Ed) 2001, 6(3), 355–365;
Published: 1 March 2001
(This article belongs to the Special Issue Lipid and lipoprotein metabolism)

Differences in LDL and HDL subclass distribution contribute to increased CAD risk through a variety of mechanisms. The inherited disorder characterized by an abundance of small, dense LDL particles increased CAD risk 3-fold and is associated with rapid arteriographic progression. The metabolic milieu associated with the small LDL trait includes insulin resistance, increased IDL, increased susceptibility to oxidative damage, impaired reverse cholesterol transport, and increased post prandial lipemia. Recent evidence indicates that the LDL IIIa+b region are the LDL subclass regions most associated with atherosclerosis. Improvement in LDL subclass distribution has been associated with arteriographic improvement significantly more than LDLC change. Therapeutic treatments including diet, and many pharmacologic interventions have a differential response in subjects characterized by an abundance of either small, or large LDL particles. Individual patient information regarding LDL and HDL subclass distribution can be used to improve medical management of the CAD patient that results in improved outcomes.

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