New insight in cdk9 function: from Tat to MyoD

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Article

Cristiano Simone^1,2, Antonio Giordano^1,*

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¹ Dept. of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA

² Dept. of Internal Medicine and Public Medicine, Division of Medical Genetics, University of Bari, Bari 70124 Italy

Academic Editor: Antonio Giordano

Front. Biosci. (Landmark Ed) 2001, 6(3), 1073–1082; https://doi.org/10.2741/simone

Published: 1 September 2001

(This article belongs to the Special Issue Gene targets for modulating cell growth)

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Abstract

Cdk9 is a serine-threonine cdc2-related kinase and its activity is not cell cycle-regulated. Cdk9 function depends on its kinase activity and also on its regulatory units: the T-family cyclins and cyclin K. Recently, several studies confirmed the role of cdk9 in different cellular processes such as signal transduction, basal transcription, HIV-Tat- and MyoD-mediated transcription and differentiation.

All the referred data strongly support the concept of a multifunctional protein kinase with specific cytoplasmic and nuclear functions.

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