IMR Press / FBL / Volume 6 / Issue 3 / DOI: 10.2741/scanu

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Apolipoprotein(a): structure and biology
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1 Departments of Medicine and Biochemistry and Molecular Biology, University of Chicago, Chicago, Illinois 60637, USA
2 University of Chicago, Chicago, Illinois 60637

Academic Editor: David Hui

Front. Biosci. (Landmark Ed) 2001, 6(3), 546–554;
Published: 1 March 2001
(This article belongs to the Special Issue Lipid and lipoprotein metabolism)

Apolipoprotein(a), apo(a), the distinctive glycoprotein constituent of lipoprotein(a), Lp(a), is synthesized in the liver, links covalently to apoB100-lipoprotein, and travels so linked in the plasma to tissue sites where removal mechanisms are yet undetermined. Depending on the redox status of the surrounding milieu, apo(a) may re-acquire its unbound state shown to have structural and functional properties different from those of the bound form. Apo(a) is potentially athero-thrombogenic, a property which may be influenced by its size, sequence polymorphism, type of lipoprotein it is linked to and the inflammatory state of the vessel wall. This set of variables must be taken into account when assessing the cardiovascular pathogenicity of free and bound apo(a).

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