IMR Press / FBL / Volume 6 / Issue 3 / DOI: 10.2741/ploplis

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Gene targeting in hemostasis. plasminogen
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1 W.M. Keck Center for Transgene Research and the Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN 46556, USA

Academic Editor: Francis Castellino

Front. Biosci. (Landmark Ed) 2001, 6(3), 555–569;
Published: 1 March 2001
(This article belongs to the Special Issue Gene targeting in hemostasis)

A number of in vitro and in vivo observations have implicated plasminogen in contributing to events associated with diverse physiological and pathophysiological processes. The development of gene knockout technology has led to the generation of plasminogen deficient mice. These mice survive to adulthood and are thus a valuable resource for directly assessing its role in these processes. As a result, fibrinolytic and nonfibrinolytic functions have been identified from studies in which these mice were challenged utilizing a number of models that mimic both normal biological and pathological events.

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