IMR Press / FBL / Volume 6 / Issue 3 / DOI: 10.2741/navarro

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Skeletal muscle and aging
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1 Department of Biochemistry and Molecular Biology, Faculty of Medicine. University of Cádiz. Plaza Fragela No 9. 11003-Cadiz. Spain
2 Department of Cell Biology, Faculty of Medicine. University of Cádiz. Plaza Fragela nº 9. 11003-Cádiz. Spain
3 Department of Biochemistry and Molecular Biology, Faculty of Medicine. University of Cádiz. Plaza Fragela nº 9. 11003-Cádiz. Spain

Academic Editor: Victor Preedy

Front. Biosci. (Landmark Ed) 2001, 6(3), 26–44; https://doi.org/10.2741/navarro
Published: 1 January 2001
(This article belongs to the Special Issue Cellular and molecular aspects of muscle pathology)
Abstract

Age-related changes in muscle mass (sarcopenia) and functional properties are the result of a very complex hierarchical system of basic cell aging processes and cell adaptive responses. A basic aging mechanism pertains to mitochondrial production of free radicals and their associated secondary effects. From this basic aging mechanism many other cellular changes can be explained as direct effects or compensatory changes. Altered skeletal muscle cell biochemical and functional properties during aging resulting from intrinsic mechanisms and from changes in hormonal or local signals that influence phenotype maintenance, are reviewed. The effect of skeletal muscle cell senescence on the cellular response to exercise, and the effect of dietary restriction on muscle cell senescence can also be explored from this perspective.

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