IMR Press / FBL / Volume 6 / Issue 3 / DOI: 10.2741/horn

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
The bromodomain: a regulator of ATP-dependent chromatin remodeling?
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1 University of Massachusetts Medical School, Program in Molecular Medicine, 373 Plantation St., Worcester, MA 01605, USA

Academic Editor: Gerald Denis

Front. Biosci. (Landmark Ed) 2001, 6(3), 1019–1023; https://doi.org/10.2741/horn
Published: 1 August 2001
(This article belongs to the Special Issue The role of bromodomain proteins in the cell cycle and cancer)
Abstract

In eukaryotes, processes requiring access to DNA are inhibited by the structural packaging of the genome. A number of specialized ATP-dependent chromatin remodeling enzymes have evolved to overcome this inhibition. One subset of these enzymes, SWI/SNF, plays a critical role in the regulation of transcription, often functioning in concert with nuclear histone acetyltransferases (HATs). It remains unknown how these activities are coordinated. However, recent results revealing that the bromodomain, a motif common in these remodeling factors, constitutes an acetyl-lysine binding domain might provide insight into this process. Bromodomains may serve a role analogous to the signal transduction SH2 domain, by providing a means to recruit remodeling complexes to acetylated chromatin regions or to allosterically modify their function post-recruitment.

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