IMR Press / FBL / Volume 6 / Issue 3 / DOI: 10.2741/hoffman

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
T cells in the pathogenesis of systemic lupus erythematosus
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1 Division of Immunology and Rheumatology, University of Missouri, One Hospital Drive, Columbia, Missouri, Department of Veterans Affairs Medical Center, 800 Hospital Drive, Columbia, Missouri

Academic Editor: Robert Hoffman

Front. Biosci. (Landmark Ed) 2001, 6(3), 1369–1378; https://doi.org/10.2741/hoffman
Published: 1 October 2001
(This article belongs to the Special Issue Pathogenesis of systemic lupus erythematosus)
Abstract

The role of T cells in the pathogenesis of systemic lupus erythematosus (SLE) is reviewed with a focus on autoantigen-specific T cells in SLE. The initial clue to a role for T cells in SLE was histopathologic studies demonstrating extensive infiltration of T cells at the sites of inflammation. Later studies, showing association between HLA polymorphisms and specific autoantibodies, directly implicated a role for T cells in autoantibody production. More recently, we and others have identified and characterized autoantigen-specific T cells in SLE. We review these studies on the role of autoantigen-specific T cells in SLE and present new findings on the molecular characterization of T cell immunity to Sm-B, Sm-D and U1-70kD small nuclear ribonucleoprotein (snRNP) autoantigens.

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