IMR Press / FBL / Volume 6 / Issue 3 / DOI: 10.2741/greidinger

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Apoptosis in lupus pathogenesis
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1 Division of Immunology and Rheumatology, University of Missouri, One Hospital Drive, Columbia, Missouri 65212, USA
Front. Biosci. (Landmark Ed) 2001, 6(3), 1392–1402;
Published: 1 November 2001

Apoptosis has been implicated in lupus pathogenesis in at least three different ways. As antigen, apoptotic material drives autoimmune responses. As immune modulator, impaired apoptosis makes patients susceptible to developing autoimmunity. As effector mechanism, apoptosis participates in target organ injury. This review summarizes the evidence that links apoptosis to these components of lupus pathogenesis.

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