IMR Press / FBL / Volume 6 / Issue 3 / DOI: 10.2741/greidinger

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Apoptosis in lupus pathogenesis
Show Less
1 Division of Immunology and Rheumatology, University of Missouri, One Hospital Drive, Columbia, Missouri 65212, USA
Academic Editor:Robert Hoffman
Front. Biosci. (Landmark Ed) 2001, 6(3), 1392–1402; https://doi.org/10.2741/greidinger
Published: 1 November 2001
(This article belongs to the Special Issue Pathogenesis of systemic lupus erythematosus)
Abstract

Apoptosis has been implicated in lupus pathogenesis in at least three different ways. As antigen, apoptotic material drives autoimmune responses. As immune modulator, impaired apoptosis makes patients susceptible to developing autoimmunity. As effector mechanism, apoptosis participates in target organ injury. This review summarizes the evidence that links apoptosis to these components of lupus pathogenesis.

Share
Back to top